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In Sanctum 2, the player has access to various perks, which help them defend the Core. Initially, most of the perks are locked, but they progressively become unlocked as the player ranks up. At rank 20, the player has unlocked all perks and can use three perks simultaneously.

Perks are activated before starting when the player is choosing their Guardian, Weapons, and Towers.

Adrenaline Rush
  • Increases your movement speed by 3% for each hit on the enemy.
  • Stacks up to 60%.
  • Each instance lasts 7.5 seconds.
Adrenaline Rush
Against All Odds
  • Increases your damage by 10% for each enemy that is close to you.
  • Stacks up to 50%.
Against All Odds
Best Friends Forever
  •  ?
Bloodletter
  •  ?
Collateral Damage
  •  ?
Consuming Rage
  • The more damaged you are, the more bonus damage you deal.
  • Max 50% bonus damage.
Consuming Rage
Core Guardian
  • The closer you are to the Core, the more bonus damage you deal.
  • Max 50% bonus damage.
Core Guardian
Core-Tower Synergy
  • Towers deal 0.6% additional damage for each percent of Core health that was lost during the previous wave.
Core-Tower Synergy
Corpse Explosion
  • When you kill an enemy it explodes, and nearby enemies take damage equal to 25% of its maximum health.
Corpse Explosion
Desperate Measures
  •  ?
Electrical Outburst
  • Deals 1000 damage in an area around an enemy when you damage it. Enemies that take damage from this will take additional damage over time. Has a cooldown on 10 seconds.
  • Unlocked at player level 23.
Engineer
  • All nearby towers deal 25% more damage.
Engineer
Exposure Rounds
  • When you damage an enemy it takes 15% additional damage from all sources for 5 seconds.
Exposure Rounds
G2 Companion
  • Haigen's hobby project G-2 is a little companion that follows you faithfully and helps you fight stuff.
  • Unlocked at player level 21.
Hip Fire
  • Increases all damage done by 40% (including Sweet's burn).
  • Disables weakspot hits.
Hip Fire
Hollowpoint Rounds
  • Every third shot deals bonus damage equal to the shot's base damage.
Hollowpoint Rounds
Hydra Blood
  •  ?
Long Range Specialization
  • Spread on your weapons is reduced by 50%.
  • Explosion size is increased the longer your projectiles travel.
  • Maximum 300% explosion size.
Long Range Specialization
Long Range Superiority
  •  ?
Marksman
  • Increases weakspot damage by 45%.
Marksman
Overcharge
  • Electrical bolts hit enemies close to you for 666 damage once every second.
Overcharge
Parthian Tactics
  •  ?
Penetrator Rounds
  • Shots that hit weakspots will penetrate and deal 200% damage to enemies in its path.
Penetrator Rounds
Phoenix
  • Allows you to respawn instantly.
  • When you respawn, you have a 25% damage bonus for 15 seconds.
  • Still works when the Feat of Strength Hardcore is active, but you must wait the normal ten seconds before respawning.
Phoenix
Plumber Shoes
  • You deal 4000 damage to enemies that you land on.
  • Increases air control.
Plumber Shoes
Reinforcements
  •  ?
Resilient Core
  • Heals the Core for 10% of its max health at the end of each action phase.
  • Stacks if equipped by more than one player.
  • Affects all Cores on the map.
  • A Core cannot exceed its max health.
Resilient Core
Roboticist
  •  ?
Rymdskor
  • Gives you a 25% speed boost.
  • Provides you with an extra midair jump (Skye can perform a triple-jump).
Rymdskor
Shocking Revelation
  • When an enemy damages the Core, the Core releases a shockwave that stuns nearby enemies.
  • 10-second cooldown.
Shocking Revelation
Slowing Presence
  • Nearby enemies are slowed by 20%
Slowing Presence
Slowing Rounds
  • Enemies damaged by you are slowed by 20% for 2.5 seconds.
Slowing Rounds
Spiked Armor
  •  ?
Static Discharge
  • Adds a lightning bounce to your shots that deal 50% of damage done to another close enemy.
  • 0.25-second cooldown.
Static Discharge
Steady Aim
  •  ?
Synergy
  • Enemies that are damaged by you take 30% extra damage from towers for 4.5 seconds.
Synergy
Tactical Juxtaposition
  • Slow Weapons
    • 200% Fire Rate
    • 200% Ammo
    • 60% Damage
  • Fast Weapons
    • 50% Fire Rate
    • 50% Ammo
    • 250% Damage
Tinkerer
  • The last 3 towers you built deals 30% more damage.
  • Unlocked at player level 22.
Trickster
  • Give you the ability to dodge by double-tapping in the direction you want. Increases damage done by 10%.
  • Unlocked at player level 21.
Upper Class
  •  ?
Unstable Core
  • Deals 2000 to enemies each time they hit the core.
Unstable Core

Sanctum 2

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